Monroe Carell Jr. Children's Hospital at Vanderbilt
Monroe Carell Jr. Children's Hospital at Vanderbilt
Monroe Carell Jr. Children's Hospital at Vanderbilt
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Monroe Carell Jr.
Children's Hospital
at Vanderbilt
2200 Children's Way
Nashville, TN 37232

(615) 936-1000

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Liver Diseases that May Lead to Transplant


Liver transplant removes your child’s diseased liver and replaces it with a heathy liver.  While liver transplant is not indicated for everyone, the following liver diseases may lead to liver transplantation:

Obstructive Biliary Tract Liver Disease

Metabolic Diseases

  • Alpha-1 antitrypsin deficiency
  • Gestational alloimmune liver disease (GALD/neonatal hemochromatosis)
  • Glycogen storage disease, Types 1, 2, 3, 4
  • Maple syrup urine disease (MSUD)
  • Tyrosinemia
  • Urea cycle deficiencies
  • Wilson’s disease

Acute and Chronic Hepatitis

Acute (fulminant) hepatic failure

  • Toxin or drug induced
  • Viral induced

Chronic active hepatitis with cirrhosis

Intrahepatic Cholestasis

  • Alagille syndrome
  • Progressive familial intrahepatic cholestasis (PFIC/Byler disease)
  • Idiopathic neonatal hepatitis

Hepatic tumors (liver tumors)

  • Hepatoblastoma
  • Hepatocellular carcinoma
  • Other hepatic tumors

Other Liver Diseases

  • Budd-Chiari
  • Caroli disease (ARPKD – Autosomal recessive polycystic kidney disease)
  • Cirrhosis - secondary to prolonged total parenteral nutrition (TPN)
  • Congenital hepatic fibrosis
  • Cryptogenic cirrhosis
  • Cystic fibrosis

Indications for Liver Transplant in Children

Last Edited: October 26, 2016
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