Roland D. Eavey, M.D.
Dr. Roland D. Eavey researches and studies the causes and treatment of microtia and aural atresia. Microtia means "little ear." Microtia ears can vary in appearance; most microtia ears are shaped like a small "peanut" or "figure-of-eight" and associated with aural atresia (aural atresia means that the ear canal has not opened). Projects include cutting-edge tissue engineering as well as molecular genetics research.
Steve Goudy, M.D.
Dr. Steve Goudy has researched the basic developmental processes of facial formation. Current projects include studying a gene that leads to a very common form of cleft lip and palate. The goal is to study which genes are necessary for proper lip and palate development and determine if there are any preventative steps that can be taken. These results may point the way towards providing a personalized approach to each patient with craniofacial disorders in the future, tailoring their medical and surgical care based on their specific genetic makeup.
OK-432 (Picibanil) Sclerotherapy: A Multi-Center Study
Dr. Goudy is also directing efforts for the Vanderbilt site of a phase III clinical trial of OK-432 (Picibanil). The major objective of this study is to test the safety and activity of OK-432 (Picibanil) sclerotherapy in the treatment of macrocystic lymphangiomas of the head and neck in pediatric patients. Lymphatic malformations are uncommon hamartomas that represent localized malformations in the development of the lymphatic system.
Morbidity can be significant. Besides the obvious cosmetic deformity caused by these tumors, there is risk of infection and upper aerodigestive tract obstruction. However, effective therapeutic options are limited. Small lesions can be observed, although spontaneous resolution is unlikely; for larger lesions, surgery has been the traditional form of therapy. Total excision is curative, however because lymphangiomas are not malignant, the extent and morbidity of the extirpation must be balanced by the morbidity caused by the tumor. In the head and neck, in particular, lymphangiomas typically insinuate themselves around major neurovascular structures, effectively precluding complete removal and making the likelihood of recurrence high.
Because of these surgical limitations, alternate therapies have been considered, including cryotherapy, diathermy and chemical sclerotherapy. Although neither of the first two treatment modalities is effective, the use of sclerotherapy using OK-432 in a subgroup of Japanese patients with lymphangiomas who have been followed for up to 10 years has been effective. The initial experience with OK-432 in the United States also has been promising. The incidence of lymphatic malformations is low, making it an orphan disease, but these problems are difficult to deal with and recurrence with surgical therapy does occur. View a list of Dr. Goudy's selected publications.
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